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Interestingly, the silencing of -catenin with siRNA abolished the effect of Ex-4 on these genes, suggesting dependency on the Wnt/-catenin pathway
Importantly, large-scale randomized trials, meta-analyses, and observational studies suggest that GLP-1RAs do not significantly increase AKI risk and may even confer renal benefits in high-risk populations
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95% CI 0.90, 1.01) and cerebrovascular events (HR 0.99
