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[DOI] [PubMed] [Google Scholar] 104.VI N.B., Tressler E.H., Vendruscolo L.F., Leggio L., Farokhnia M

Subsequent development as an obesity drug was discontinued due to the small effect size, though research continues on its potential role in cartilage repair and localized metabolic applications

However, there were no significant differences between tirzepatide 5 mg and semaglutide 2 mg in terms of HbA1c and body weight reductions

But even major weight loss from diet and exercise alone would cause these changes

Many patients experience brief plateaus lasting 412 weeks, which typically resolve with minor dietary adjustments or, rarely, dose modifications