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Tapering versus abrupt cessation The clinical trials did not specifically study tapering protocols, but physiological principles suggest a gradual dose reduction may produce a smoother transition than abrupt cessation

This dip in energy can trigger cravings for more sugary or high-carb foods later in the evening

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Engineered cells implanted in mice detect and respond to both physiological and experimentally manipulated melatonin, producing GLP-1 at night or in response to exogenous melatonin