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10.1016/s0140-6736(08)61206-4 24 DruckerD

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Some people are unable to tolerate the drugs because of their side effects, particularly severe nausea and diarrheaa 2021 study showed 4.5 percent of people taking semaglutide discontinued the drug because of gastrointestinal issues
The largest psychiatric meta-analysis to date 80 randomized controlled trials, over 107,000 patients also found significant improvements in restrained eating and emotional eating with GLP-1 medications compared to placebo ( Pierret et al., JAMA Psychiatry, 2025 )
Compr Physiol 3 , 485513, (2013)
