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One subject randomized to liraglutide 1.2 mg had antibodies that crossreacted to GLP-1 in vitro at the end of the trial (the subject was exposed to both liraglutide 2.4 and 3.0 mg during the extension period)

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In summary, this investigation has unveiled the existence of a newly characterised inter-organelle signalling hub in pancreatic -cells which involves active endosomal GLP-1R localisation to ERMCSs via VAPB binding and engagement of the AKAP SPHKAP to enable ERMCS-restricted cAMP/PKA activity via the assembly of PKA-RI biomolecular condensates, leading to PKA phosphorylation of the MICOS complex, enhanced mitochondrial remodelling and improved mitochondrial function, with important implications for the modulation of -cell function and survival and the potential to serve as a mechanism for GLP-1R-induced mitochondrial adaptation during metabolic stress and excess nutrient exposure