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Primary Handling Editors: Revati Dewal, Christoph Schmitt and Isabella Samuelson, in collaboration with the Nature Metabolism team

Neither GLP-1 agents nor naltrexone are FDA-approved specifically as a combination therapy for weight management

The ADA titer at baseline ranged from 1:10 to 1:10 240 (median 1:20)

Clinical trials demonstrating Ozempic efficacy used weekly dosing specifically because this schedule maintains steady GLP-1 receptor activation

However, more rigorous research, including randomized clinical trials, is still needed to fully understand the effectiveness and long-term efficacy of e-cigarettes as a smoking cessation tool