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Description
A separate class-level subgroup analysis excluding trials with study populations least comparable to SURPASS-CVOT, specifically ELIXA, which enrolled patients with recent acute coronary syndrome (within 180 days of medication initiation), and FLOW, a dedicated CKD outcomes trial

This high concentration means you draw a very small volume for your target dose (higher precision risk)
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While individual variation exists, it is not large enough to justify a two-day schedule reduction

It was FDA approved in 2023 and has shown impressive results so far
