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The Wegovy and Rybelsus pills use an absorption enhancer called sodium N-(8-[2-hydroxybenzoyl]amino) caprylate (SNAC), which protects the drug from stomach acid and enzymes, allowing it to survive long enough to be absorbed through the stomach lining and into the bloodstream

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Both the 2016 consensus statement of the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) on management of type 2 diabetes and the 2016 American Diabetes Association (ADA) standards recommend adding on GLP-1 RAs to patients not meeting treatment goals with basal insulin

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The last dose is usually taken the day before or two days before the first tirzepatide injection