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Peripheral but not central administration of GLP-1 fails to inhibit angiotensin (ANG) II-induced drinking in rats that have been treated with monosodium glutamate (MSG) to induce damage of the ARC and the sensory circumventricular organs, suggesting that peripherally administered GLP-1 effects drinking behavior via CNS-dependent mechanisms [760]

While lean mass typically accounts for about one-quarter of total weight lost, this pattern is comparable to other weight-loss approaches and not uniquely harmful

-1 : - Very interesting paper just published in eClinicalMedicine by Brajan Budini and colleagues

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Although variable between mice, SKO mice administered with liraglutide released very high levels of insulin in response to glucose, 8 times higher than those of PBS-treated SKO mice and 40 times higher than those of liraglutide-treated WT mice