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Less common but notable side effects include headaches , muscle pain , fatigue , anxiety , sleep disturbances , injection site reactions , and body aches

D., Schneider, M

These results suggest that for patients already receiving a GLP-1 RA who require additional treatment for glycaemic control, a switch to semaglutide could provide HbA1c and weight benefits without the need for more frequent administration

Positron emission tomography validated high GLP-1R and GcgR engagement with SAR441255 in lean monkeys, however GIPR engagement was reported to not be effectively assessed due to a lack of a suitable radiotracer [17]

[cited 9 July 2025]