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Retatrutide is contraindicated during pregnancy and breastfeeding

Safety really comes down to proper dosing and patient selection by a licensed provider. A 2025 review that assessed the safety profiles of both drugs found that the most common adverse effects are the same for both tirzepatide and semaglutide, namely, nausea, vomiting and diarrhea

Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence

These supplements support heart health and can reduce the risk of adverse events associated with diabetes and GLP-1 medications