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Experimental investigations have demonstrated that cholangiocytes are sensitive to GLP-1 and respond with augmented proliferation, potentially increasing the risk of duct obstruction [47,48]

As the disease progresses, scar tissue builds in the liver, eventually impairing its ability to function

In a combined analysis of subcutaneous (SUSTAIN-6) and oral [PIONEER 6 (NCT02692716)] T2DM CVOTs, semaglutide consistently reduced MACE risk versus placebo across all eGFR and urinary albumin:creatinine ratio (UACR) subgroups [58] Additionally, semaglutide (SELECT) reduced MACE in participants with overweight/obesity and baseline CVD but no T2DM [48]

For people living with both type 2 diabetes and obesity, a prescriber might consider either, alongside other medications, based on the wider picture of someones health

This indicates that when evaluating the efficacy of different GLP-1RA drugs, varying treatment durations should be employed to fully reflect the therapeutic potential of each drug