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Retatrutide is the only compound that attacks the energy balance equation from both sides: reducing appetite through GLP-1 and GIP activity, while simultaneously increasing energy expenditure and fat oxidation through glucagon receptor activation

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In the STEP programme, participants with obesity and prediabetes experienced substantial improvements in insulin sensitivity markers, with many reverting from impaired glucose tolerance to normoglycaemia

In parallel, this research has generated new insights into the cellular and molecular mechanisms underlying the immunoregulatory functions of the vagus nerve within the inflammatory reflex

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