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Although the effects of these drugs were studied only for 2 weeks, they produced an average 20% body weight decrease, twice the effect of semaglutide alone

Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice

This is one reason why the 4mg to 8mg transition often produces the most dramatic changes in body composition

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Some people simply tolerate one better, and switching is always an option
