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While this effect has not been confirmed in humans, patients with a personal or family history of medullary thyroid carcinoma should avoid semaglutide

Be aware that prolonged use can lead to rebound congestion

Eng hypothesized it might produce a hormone to modulate insulin for those big meals ( [78] ) ( [79] )

Such findings led scientists to label AOD-9604 as the worlds first drug with a metabolic mechanism of action for obesity meaning it works by accelerating fat metabolism rather than suppressing appetite