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It has also been demonstrated that inhibitory GABAergic CNS GIPR + neurons are necessary for the food intake reducing effects of GIPR agonists and dual incretin co-agonists (54, 55), while excitatory glutamatergic CNS GLP-1R + neurons are necessary for the food intake reducing effects of GLP-1R agonists (71)
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At the same time, investigators and clinicians observing outcomes in controlled and real-world research contexts have noted something more subtle and complex: changes in motivation, pleasure, and reward processing , sometimes described as emotional flattening or anhedonia in certain test subjects
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Acar A, Erba O
