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Electrolyte imbalances (sodium, potassium, magnesium) can occur rapidly during concurrent GLP-1 use and acute illness
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Further investigations of inherent variations of the GIPR within the normal population reveal that the missense GIPR variant, rs1800437 (Glu354Gln) that results in diminished GIPR signalling, leads to lower BMD and increased risk of non-vertebral fractures in perimenopausal Danish women
Dual and triple agonist therapies currently in development may expand the number of future pharmacotherapy options
These findings highlight the importance of assessing the signaling pathways engaged by therapeutic agonists for optimal clinical outcomes
