glp 1 agonists and sglt2 inhibitors Diabetic Agents, From Metformin to GLP1 Receptor Agonists: JACC Focus Seminar APhA 2025: GLP-1 Receptor Agonists

A positive outcome of adding Wegovy to formularies is the reduction of inappropriate use of Ozempic for indications other than diabetes

Following FDA clearance of its IND application, the randomized, double-blind, single ascending dose study will evaluate the safety, tolerability, and body weight changes in healthy adults with a BMI of 30 or greater

When other receptor antagonists are administered, a compensatory increase in the circulating hormone levels is seen (115)

While the TriNetX database allows for the analysis of large T2D cohorts treated with GLP-1 RAs in clinical settings, it may not capture intraclass and interclass differences between medications and prescribing patterns

For instance, while semaglutide GLP-1 can lead to greater weight loss than liraglutide, both medications are known to cause side effects, such as nausea and gastrointestinal discomfort