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Description
Lilly gained a perceived competitive edge in 2025 when Zepbound (tirzepatide) overtook Wegovy (semaglutide) in US prescriptions, and orforglipron became the first oral small-molecule GLP-1R agonist approved (April 2026)
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While the consistency of the association across comparator therapies and the scale of the dataset support the signals clinical relevance, biological plausibility remains hypothesis-generating and is based on investigator interpretation rather than validated mechanistic evidence
Preliminary Review Finds No Link Between GLP-1 Receptor Agonists and Suicidality
The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres
