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resolve with titration.[1][43] Absolute Contraindications : History of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2.[3][44] Relative Contraindications : Pancreatitis, severe GI disease, pregnancy/breastfeeding.[1][45] Monitoring Parameters : HbA1c, lipids, liver enzymes, renal function every 3 months.[4][46] Regulatory Status FDA Classification : Investigational (Phase 3)

A primary cardiovascular endpoint event (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) occurred in 6.5% in the semaglutide group and 8.0% in the placebo group (hazard ratio, 0.80

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