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Particularly noteworthy were the marked differences in serious metabolic and renal complications: lactic acidosis (monotherapy: n = 15,789 vs combination: n = 567), acute kidney injury (7694 vs 675), diarrhea (6922 vs 3890), and metabolic acidosis (4713 vs 203)

doi: 10.1001/jamainternmed.2024.2525

While obesity can lead to other conditions, it is also an independent disease worthy of pharmacological interventions, even when it affects nondiabetic people who may otherwise be characterized as metabolically healthy, the researchers say