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One study in rats found an increase of energy expenditure upon i.v

Heart rate elevation and autonomic effects One of the most consistent physiological effects observed with GLP-1 RAs is a modest, dose-dependent increase in heart rate, typically ranging from 2 to 5 beats per minute

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Triglyceride z-scores were borderline significantly associated with Glucagon z-scores in both girls ( p = 0.052) and boys ( p = 0.061
Discontinuation was common: 54.2% of the patients in the study data discontinued their GLP-1 RA (30 days without medication on hand), highlighting the need for additional research on the role of shortages, adverse events, and costs