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GEP44 was developed based on extensive structureactivity relationship studies and earlier preliminary in vivo studies that demonstrated its greater efficacy at reducing both food intake and body weight compared to the agonist peptide, Ex-4, without triggering gastrointestinal distress (as assessed by kaolin intake and behavioral scoring as a proxy for nausea in rats and direct evidence of emesis in shrews) 16

Future studies should focus on exploring the underlying mechanisms and validating our findings in larger multicenter cohorts

Calcium, iron, and certain supplements also interfere with levothyroxine absorption

However, consistent lifestyle choices are what make these changes last