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Age, diabetes status, and concurrent blood pressure medications also modify risk

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Thus, the authors emphasized the importance of informing patients, particularly those at elevated risk, about this potential adverse effect, while also highlighting the need for further research to elucidate underlying mechanisms and optimize therapeutic benefits [140]

In addition, the C-domains of LCDV1-VILP and IGF-1 are of similar length (10 vs 12 amino acids) and share 33% sequence identity, including Arg37, one of the residues in the IGF-1 C-domain known to be involved in the receptor binding interaction 41