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Effect of glucagon-like peptide-1 receptor agonists in type 2 diabetes

Serotonin and GLP-1 agonists While the interaction between GLP-1 and serotonin within the central nervous system is an emerging area of research, it is known that GLP-1 receptors are particularly concentrated in the nucleus tractus solitarius (NTS), a structure in the brainstem responsible for key homeostatic functions, including appetite regulation
1 and Table 2)

Excluding these two cases (n=6), insulin dose reduction over 1 year was significant (p =0.044) at 12 months (-44 66 units per day) but with no significant difference when assessed by units/kg (p=0.158, ns)
