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Activating GIP receptors appears to promote bone formation and inhibit bone resorption, at least in preclinical studies

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The SURMOUNT-1 trial published in the New England Journal of Medicine demonstrated remarkable results: participants achieved an average weight loss of 15% to 20.9% of their total body weight over 72 weeks, compared to just 3.1% in the placebo group

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27 The mean eGFR was 62 ml/min/1.73 m, and 76% of patients had NYHA class II symptoms