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In addition, Notch signaling mediates G1/S cell cycle progression through overexpression of Cyclin D3 and CDK4 in T cells (Joshi et al., 2009) and through reduction of p27 KIP1 , leading to more rapid cell cycle progression in T-cell acute lymphoblastic leukemia cells (Dohda et al., 2007)

Although obese patients have a higher risk of developing HF, they tend to show better short- and intermediate-term survival rates than leaner patients after an HF diagnosis [19]

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