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Therefore, T2DM continues to burden global health systems and is associated with high mortality rates [1,2]

The activation of GPCRs coupled to Gi/Go, Gq, and G 12/13 activates serum-response element (SRE)-mediated transcription

GLP-1R and GIPR are class B G protein-coupled receptors (GPCRs) that signal through the Gs-cAMP pathway, coupling hormone binding to downstream insulin secretion and cellular glucose uptake

Results showed that subcutaneous exenatide increased postprandial EF independently of glucose and triglyceride reductions

Clostridium butyricum produces the postbiotic butyrate which stimulates GLP-1. Bifidobacterium infantis produces the postbiotic acetate, and interacts with Akkermansia and Butyricum to promote an ecosystem in the gut that naturally boosts GLP-1