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Indeed, the experience of several randomized control trials has been included in the most recent guidelines (5, 6), which recommended these classes of drugs for patients with T2DM and CVD
Eli Lilly then spurred it on further with tirzepatide a GLP-1RA and gastric inhibitory polypeptide (GIP) agonist

Ongoing Research and Development GLP-1R agonists have demonstrated significant cardiovascular benefits in addition to effectively lowering blood glucose levels, including major cardiovascular events risk reduction
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Liraglutide and exercise synergistically attenuate vascular inflammation and enhance metabolic insulin action in early dietinduced obesity