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Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

PD is typically characterized by degeneration of dopaminergic neurons, a condition that can be mimicked in experimental animals by administration of the dopaminergic neurotoxin MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin) [[840], [841], [842]]

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In addition, a SEAP (secreted embryonic alkaline phosphatase) reporter gene under the control of a minimal promoter fused to nine cAMP response elements (CRE) was introduced