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SEMA Suppresses Microglial and Astrocyte Activation in the Spinal Cord of DNP Rats To examine the inhibitory effect of SEMA on the DNP-induced activation of microglial cells and astrocytes, we stained the spinal cord using the microglial cell-specific marker IBA-1 and the astrocyte-specific marker GFAP (Figure 6 and Figure 7)

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While lifestyle changes such as a balanced diet, regular exercise, and stress management form the foundation of promoting longevity, medications like Ozempic can play a supporting role especially when weight loss and metabolic balance are difficult to achieve through lifestyle changes alone