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Description
Additionally, an obstacle to drug treatment for obesity is that the drug is perceived as ineffective because the patient gains weight again when the drug is stopped

FDA drug shortages [Internet]

This finding supports the role of glucose toxicity in DM-related dopaminergic dysfunction and cognitive impairment, suggesting that advanced glycation end products (AGEs) and their precursor methylglyoxal (MGO) are linked to cognitive impairment and changes in the dopaminergic system

However, these animal findings are concerning enough that drug manufacturers and regulatory agencies have recommended caution until we have better human data

PEX-168, Polyethylene glycol loxenatide
