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Two subjects had values 3x ULN

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In addition, activating GLP-1R reduced Iba-1, IL-1 and TNF- release and inhibited TNC microglial number and morphological changes (process retraction) following nitroglycerin administration

The FDA's 2025-2026 labeling update reinforces this picture

Advanced-phase studies (Phase 3 and 4) continue to support its core applications in diabetes and obesity, but early research into its use for neurodegenerative and liver-related disorders presents opportunities for future market growth