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Wegovy is highly effective for weight loss, with studies indicating that it may offer greater weight reduction compared to Ozempic when used for this purpose

Unlike other antihyperglycemic agents, sitagliptin/metformin is associated with little to no hypoglycemia or weight gain

However, RAS inhibition has not yet been found to prevent kidney disease among those with type 1 diabetes, normal blood pressure and without albuminuria, and also does not prevent the progression of histological changes associated with DKD at the early stage of disease [22]

They are not candidates

Medication works best when paired with physician guidance, realistic expectations, and sustainable lifestyle adjustments