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The mechanisms include weight loss reducing upper airway fat deposition, improved respiratory muscle tone with reduced adiposity, and possible direct effects on central respiratory control through GLP-1R in the brainstem

[DOI] [PubMed] [Google Scholar] [141].Gentilella R, Bianchi C, Rossi A, Rotella CM, Exenatide: a review from pharmacology to clinical practice, Diabetes, obesity & metabolism, 11 (2009) 544556

Leptin, the hormone produced by fat cells that signals energy sufficiency to the brain, drops in proportion to fat loss

This rapid appetite suppression happens because semaglutide directly mimics glucagon-like peptide-1, a natural hormone that regulates hunger signals

For dose responses, a full GLP-1 curve was included to establish the assay E max with curve fitting to a four-parameter fit