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In line with a role of hindbrain GIPR signaling in the anti-emetic effect of GIPR agonism is the observation that central (i.c.v.) administration of GIP into the 4th ventricle of rats decreases kaolin intake induced by systemic GLP-1 treatment in rats [930], and that GIPR agonism attenuates GLP-1-induced cFos neuronal activation in the AP and NTS of rats and shrews [930]

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Low blood pressure (hypotension) is generally defined as a reading below 90/60 mmHg, though symptoms can occur at higher readings in individuals whose blood pressure was previously elevated

Research presentation details: The studies will be presented during the following symposium: Retatrutide (LY3437943), a Novel GIP/GLP-1/Glucagon Receptor TriagonistObesity, NAFLD, and T2D Phase 2 Trial Results on Monday, June 26 th at 1:30pm