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Both classes are resistant to the enzymatic degradation seen for native GLP-1, which is cleaved by the DPP-IV enzyme to generate inactive metabolites and intact GLP-1 forms with low affinity for the GLP-1R

Alonso Martin takes a precision medicine approach to weight management, evaluating each patients metabolic health, laboratory results, and clinical objectives before recommending any course of treatment

doi: 10.1038/362075a0 52 HanWNHlscherCYuanLYangWWangXHWuMNet al

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Given its potency, this technically means that Retatrutide, once approved by the FDA, may be suitable for both type 2 diabetes and obesity and provide new approaches to bariatric surgery