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Any blood pressure reduction should be viewed as a beneficial additional effect rather than the primary therapeutic goal

Clinical data shows women in trials experienced slightly higher weight loss (25.3%) compared to men (22.8%), suggesting particular effectiveness for female physiology

Some individuals also experience gastrointestinal side effectssuch as nausea, bloating, or diarrhoeawhich may be exacerbated by consuming high-fat foods like ice cream, particularly in the early weeks of treatment or after dose escalation

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A Nature Medicine analysis of the structural and pharmacological data provided mechanistic context for these outcomes, linking the superior efficacy to the additive contributions of all three receptor pathways [9]