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Since 2021, GLP-1 medications have been utilized in different forms to aid obese patients (BMI 30) and overweight patients (BMI 27) with at least one weight-related condition, such as high blood pressure, type II diabetes, or high cholesterol

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This is commonly found in situations involving patients battling chronic diseases,

the endocytic adaptor Epsin binds to the ubiquitinated intracellular domain, and the resulting Clathrin-mediated endocytosis exerts a pulling force that exposes the cleavage site in the NRR [[4][4][6][5]]