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In simple terms: tirzepatide primarily focuses on appetite suppression and metabolic regulation, while retatrutide may influence both appetite and calorie burning

This is nothing to be concerned about unless your doctor advises you that you are losing weight too quickly and they may recommend a slight increase in your daily caloric intake

Combined with medical supervision, these treatments address the root causes of weight gain not just the symptoms

The SUMMIT 1 and SUMMIT 2 trials showed that patients on retatrutide achieved approximately 24% weight loss at the highest dose, compared to 1518% for tirzepatide in parallel analyses