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Nat Rev Endocrinol 19 , 201216 (2023)

In a recent observational study, individuals who discontinued semaglutide or tirzepatide within the first three months lost only 3.6% of their body weight, while those who quit between three and twelve months lost 6.8%

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GLP-1 injected subcutaneously simply took too long to reach receptors on target tissuesDPP-4 degraded the peptide within minutes