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What Research Shows About Semaglutide In the STEP-1 trial (published in the New England Journal of Medicine , 2021), adults with overweight or obesity who took 2.4 mg semaglutide weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group

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Glucagon then travels to the liver, instructs it to break down glycogen and release glucose into the bloodstream, and blood glucose levels return toward normal