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Protein is considered the most satiating macronutrient, with evidence suggesting it suppresses appetite-related hormones such as ghrelin whilst increasing peptide YY, which signals fullness

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While this might be sufficient for triggering an early increase in circulating GLP-1 during food consumption, it is also suggested that due to relatively fewer L-cells present at proximal parts compared to distal parts within small intestines seen across rodents and humans alike some other neural or humoral signals may influence release patterns concerning GLP-1 during meals

For the main analysis, changes in weight, BMI, HbA1c, and all-cause healthcare resource utilization (HCRU) after 1 year were compared among adjusted semaglutide OW and comparator SGLT2i cohorts, following inverse probability of treatment weighting (IPTW)