retatrutide glp-1 gip glucagon triple agonist receptor Sweet Temptation, bitter Truth: Diabetes in the Research Spotlight Will Retatrutide Replace Tirzepatide
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These tend to be patients with higher baseline weight, who do not significantly compensate with increased eating, and who combine the medication with dietary changes

Scand J Gastroenterol 57(7):783791

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Finally, reduction of other risk factors, such as blood pressure and cholesterol, should also be considered and appropriate medications offered

In the UK, NICE recommends GLP-1 receptor agonists for type 2 diabetes under specific circumstances, typically when metformin and other treatments have not achieved glycaemic targets, or in people with specific cardiovascular risk factors
