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CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner

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Although most studies included several medications, current guidelines recommend selecting GLP1-RAs and SGLT2is on the basis of their clinically proven benefits rather than class alone

These criteria usually involve a minimum BMI, often 30 or more, or a BMI of 27 with at least one weight-related health condition