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In endometrial cancer cells, liraglutide induces an upregulation in progesterone receptor (PGR) mRNA levels, promotes its protein expression, markedly enhances phosphorylated AMPK levels, and downregulates its downstream effector molecule p-P71S6K, ultimately inhibiting cell viability [58]

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In the survodutide arm (a GLP-1 and glucagon receptor dual agonist), liver mass dropped 55% while muscle loss in the casted leg was comparable across semaglutide, survodutide, and pair-fed controls

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