glp 1 anesthesia guidelines GLP-1 and Anesthesia: Considerations and Cautions for CRNAs Updated Guidelines on GLP-1 Agonists

( 10.1016/j.cmet.2017.11.003) [DOI] [PubMed] [Google Scholar] van Eenige R, Ying Z, Tramper N, Wiebing V, Siraj Z, de Boer JF, Lambooij JM, Guigas B, Qu H, Coskun T, et al

A landmark 2023 New England Journal of Medicine trial found that semaglutide significantly reduced the risk of major adverse cardiovascular events among adults with overweight or obesity, even in the absence of diabetes (NEJM, 2023)

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October 2023: On October 6, 2023, a proposed class action lawsuit was filed in Canada against Novo Nordisk for damages caused by Ozempic, Rybelsus, and Wegovy drugs

Appendix Abbreviations ATP adenosine triphosphate BSEP/ABCB11 bile salt export pump Ca 2+ calcium ions cAMP cyclic adenosine monophosphate CCK cholecystokinin CYP7A1 cholesterol 7-hydroxylase CYP8B1 sterol 12-hydroxylase Epac2 exchange protein activated by cAMP-2 FGF19 fibroblast growth factor 19 FGFR4 fibroblast growth factor receptor 4 FXR farnesoid X receptor GLP-1 glucagon-like peptide-1 GLP-1R GLP-1 receptor GLP-1RAs glucagon-like peptide-1 receptor agonists HNF4 hepatocyte nuclear factor 4 IR insulin resistance MASLD metabolically associated steatotic liver disease NTS nucleus of the solitary tract PKA protein kinase A SHP small heterodimer partner T2DM type 2 diabetes mellitus TGR5 Takeda G-protein-coupled receptor 5 Footnotes ORCID iDs: Mohammed Eslam Nahum Mndez-Snchez Contributor Information Mariana M