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Constipation means contents are backing up in the large intestine, which creates additional fermentation opportunity and can increase gas production throughout the entire digestive tract

Under these nonpathological conditions, coupling of glucose metabolism to K ATP channel closure is not disturbed, so that glucose is fully capable of generating the cytosolic Ca 2+ signal that stimulates insulin exocytosis

Treat the gap between them as indicative rather than precise

but frequent use of diuretics is likely to exacerbate renal dysfunction due to diuretic-induced renal hypoxia 13

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