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Conversely, early treatment phases may involve emotional adjustment
Efficacy and safety of tirzepatide monotherapy in type 2 diabetes (SURPASS-1)
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Males were also initially excluded since there were concerns about the potential for testicular toxicity at the outset of the trial that emanated from the aforementioned toxicology study in Sprague Dawley rats (see Supplementary Results for complete details of this preclinical study)
Uncontrolled hyperglycaemia increases risk of acute complications and long-term microvascular and macrovascular damage
