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The therapeutic versatility of SSRIs has led to expanding use beyond regulatory-approved psychiatric indications into off-label applications such as premenstrual dysphoric disorder (PMDD), select chronic pain conditions (e.g., fibromyalgia), and premature ejaculation, reflecting their broad prescribing across both psychiatric and non-psychiatric clinical settings [7,8]

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Abstract The vagus nerve is involved in the autonomic regulation of physiological homeostasis, through vast innervation of cervical, thoracic and abdominal visceral organs

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